TABLE I.
Top Genes Which Are Expressed Differently in HPAH and IPAH HPASMC Compared With Control Cells
| Symbol | Entrez gene name | Fold change (HPAH) | P-value (HPAH) | Fold change (IPAH) | P-value (IPAH) |
|---|---|---|---|---|---|
| Mostly upregulated genes with related biological functions | |||||
| CDC20 | Cell division cycle 20 | 2.717 | 4.02E-03 | 7.059 | 3.05E-04 |
| PLK1 | Polo-like kinase 1 | 2.517 | 5.73E-03 | 6.442 | 4.78E-04 |
| ERG | v-ets avian erythroblastosis virus E26 oncogene homolog | 8.529 | 3.40E-03 | 6.278 | 5.79E-03 |
| CDKN3 | Cyclin-dependent kinase inhibitor 3 | 2.134 | 2.51E-02 | 5.987 | 1.50E-03 |
| ANLN | Anillin, actin binding protein | 2.356 | 8.74E-03 | 5.827 | 6.49E-04 |
| CCNB2 | Cyclin B2 | 1.986 | 9.20E-03 | 5.419 | 4.72E-04 |
| CDK1 | Cyclin-dependent kinase 1 | 1.981 | 3.75E-03 | 4.634 | 1.86E-04 |
| PLXDC1 | Plexin domain containing 1 | 2.774 | 2.04E-05 | 3.712 | 1.69E-06 |
| BMP4 | Bone morphogenetic protein 4 | 2.405 | 3.17E-05 | 3.323 | 1.20E-05 |
| SMOC1 | SPARC related modular calcium binding 1 | 3.172 | 2.09E-03 | 3.304 | 1.94E-03 |
| PDPN | Podoplanin | 2.781 | 4.19E-04 | 2.998 | 2.77E-04 |
| WISP3 | WNT1 inducible signaling pathway protein 3 | 2.664 | 8.05E-05 | 2.659 | 2.04E-04 |
| CTSH | Cathepsin H | 3.57 | 1.48E-04 | 2.252 | 7.90E-04 |
| ADRB2 | Adrenoceptor beta 2, surface | 2.089 | 2.18E-04 | 2.191 | 1.48E-04 |
| DAPK1 | Death-associated protein kinase 1 | 3.125 | 1.55E-04 | 1.532 | 2.49E-03 |
| Mostly downregulated genes with related biological functions | |||||
| EDNRB | Endothelin receptor type B | –7.616 | 4.90E-04 | –2.321 | 6.53E-03 |
| CCL20 | Chemokine (C-C motif) ligand 20 | –2.526 | 9.66E-04 | –2.356 | 1.16E-03 |
| KSR1 | Kinase suppressor of ras 1 | –1.594 | 6.41E-04 | –2.452 | 1.23E-04 |
| ADAMTS5 | ADAM metallopeptidase with thrombospondin type 1 motif, 5 | –1.683 | 3.55E-04 | –2.554 | 1.02E-04 |
| MFAP4 | Microfibrillar-associated protein 4 | –2.299 | 3.96E-03 | –2.589 | 2.51E-03 |
| FOXE1 | Forkhead box E1 (thyroid transcription factor 2) | –2.693 | 2.54E-03 | –2.788 | 2.76E-03 |
| PTN | Pleiotrophin | –2.089 | 2.81E-03 | –2.951 | 6.16E-04 |
| RGS7 | Regulator of G-protein signaling 7 | –2.527 | 1.79E-04 | –3.068 | 2.07E-04 |
| TRPC4 | Transient receptor potential cation channel, subfamily C, member 4 | –3.557 | 6.01E-04 | –3.28 | 5.75E-04 |
| PCDHGA3 | Protocadherin gamma subfamily A, 3 | –2.642 | 2.05E-04 | –3.344 | 6.09E-05 |
| LPPR4 | Lipid phosphate phosphatase-related protein type 4 | –6.696 | 3.04E-03 | –4.406 | 7.10E-03 |
| PCDHB16 | Protocadherin beta 16 | –1.949 | 5.45E-03 | –5.14 | 1.83E-04 |
| EREG | Epiregulin | –6.881 | 6.81E-04 | –6.292 | 4.23E-04 |
| DSG2 | Desmoglein 2 | –5.663 | 3.97E-06 | –6.511 | 7.42E-06 |
| MXRA5 | Matrix-remodeling associated 5 | –1.815 | 2.07E-03 | –7.209 | 4.11E-05 |
The table showed the entrez gene ID, gene symbol, the fold change of mRNA expression in HPAH and IPAH samples compared with normal HPASMC, and the normalized expression value of control, HPAH, and IPAH samples of the 15 mostly upregulated and 15 mostly downregulated genes with related biological functions.