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. 2015 Apr 9;10(4):e0111108. doi: 10.1371/journal.pone.0111108

Fig 1. Sulfur amino acids biosynthetic pathway in filamentous fungi.

Fig 1

Genes encoding enzymes from the transsulfuration pathway (cysteine to methionine, CGS1, CBL1), the reverse transsulfuration pathway (homocysteine to cysteine, CBS1 and CGL1), the sulphydrylation pathway (HSAT1, HCS1), the methyl cycle (MET6, SAM1, SAHH1) and the glutathione biosynthesis pathway (GSH1, GSH2) were identified in Magnaporthe oryzae (v7) genome by similarity to known fungal genes. Proteins were designated as: Cgs1, Cystathionine γ-synthase (MGG_03583.7: met1-); Cbl1, Cystathionine β-lyase (MGG_07074.7: str3-); Cbs1, Cystathionine β-synthase (MGG_07384.7); Cgl1, Cystathionine γ-lyase (MGG_10380.7); Hcs1, Homocysteine synthase (MGG_07195.7); Hsat1, Homoserine acetyltransferase (MGG_01469.7); Met6, Methionine synthase (MGG_06712.7); Mthfr1, methylenetetrahydrofolate reductase (MGG_01728.7: met13-); Sahh1, reversible S-adenosylhomocysteine hydrolase (MGG_05155.7); Sam1, S-adenosylmethionine synthetase (MGG_00383.7); Gsh1, γ-Glutamylcysteine synthetase (MGG_07317.7); Gsh2, Glutathione synthetase (MGG_06454.7). Abbreviations: CH2 = THF, methylene tetrahydrofolate; CH3-TriGluTHF, methyl tetrahydrofolate tri-glutamate; dSAM, desoxyribosyl-SAM; MTA, methylthioadenosine; R, compound to be methylated; R-CH3, methylated compound; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine; SAM, S-adenosylmethionine; S2-, sulphur; SO4 2-, sulphate; THF, tetrahydrofolate. Known fungal mutants are highlighted by grey boxes. Met6 is highlighted by a black box.