Table 1.

Summary of Palivizumab Regimens

Regimen (Source)	Total No. of Doses	Days of Coverage	Date of First Dose	Interval, d
Regimen (Source)	Total No. of Doses	Days of Coverage	Date of First Dose	Between Doses 1 and 2	After Dose 2
Seasonal (Pickering et al,¹¹ 2014)	5	159	Onset of local RSV season	30	30
NOV1 (Pickering et al,¹¹ 2014)	5	159	Nov 1	30	30
MED30 (Panozzo et al,¹⁷ 2010)	5	159	30 d before onset of 5 past local seasons	30	30
OFS (present study)	5	181	Optimized to local RSV data^a	29	38
OFS4 (present study)	4	143
OFS3 (present study)	3	105

Abbreviations: MED30, initiates injections 30 days before the median start date across the 5 most recent RSV seasons; NOV1, recommends the first injection occur on November 1; OFS, optimized fixed start; OFS3, 3-injection OFS; OFS4, 4-injection OFS; RSV, respiratory syncytial virus.

Injections are timed so to achieve protective concentrations of palivizumab on days of the year when the hospitalization rate is the highest based on local data from previous seasons.