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. 2015 Apr 9;10(4):e0122916. doi: 10.1371/journal.pone.0122916

Fig 8. Virulence in a mouse model.

Fig 8

A. No significant difference was found between H99, H99 carrying the empty targeting plasmid, and the ade2Δ strain complemented with ADE2 using the safe haven targeting plasmid. While the ade2Δ mutant and the ade2Δ strain carrying the empty safe haven showed no significant difference from each other, a significant difference in survival was seen between each and H99 (P<0.0001). Significant differences were also observed between H99 and complemented strains Random #1, Random #2 and Genomic Location (P<0.0001, P<0.0001 & P<0.05 respectively).