Figure 2. Exon skipping and alternative splice site usage increased in U2AF1 (S34F) mutant samples.
U2AF1 (S34F) caused increased exon skipping in (a) DEK and increased utilization of a 3’ alternative splice site in (b) SERPIN8B in transfected CD34+ cells (left panels) and primary MDS samples (right panels). Arrows indicate primers used for RT-PCR. Data in the left panels represent mean +/- SD of 3 technical replicates, repeated in 3 biological replicates with similar results. **P<0.01, ***P<0.001.