Table 4. Univariate and multivariate Cox regression analyses results for evaluating variables associated with overall survival in patients receiving perioperative blood transfusions.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Unadjusted HR | 95% CI | p-value | Adjusted HR | 95% CI | p-value | |
| Age (dichotomized) | ||||||
| <60 y | Reference | Reference | ||||
| ≥60 y | 1.90 | 1.18-3.07 | 0.008 | 2.07 | 1.27-3.38 | 0.003 |
| BMI (dichotomized) | ||||||
| <25 kg/m2 | Reference | Reference | ||||
| ≥25 kg/m2 | 0.61 | 0.38-0.98 | 0.042 | 0.61 | 0.37-0.98 | 0.041 |
| Preoperative Hb (continuous) | 0.87 | 0.78-0.96 | 0.009 | 0.95 | 0.85-1.07 | 0.452 |
| Total transfused units (dichotomized) | ||||||
| ≤4 | Reference | Reference | ||||
| >4 | 1.64 | 1.13-2.40 | 0.009 | 1.69 | 1.15-2.49 | 0.007 |
| EBL (continuous) | 1.00 | 1.00-1.001 | 0.003 | 1.00 | 1.00-1.00 | 0.883 |
| Pathologic tumor stage | ||||||
| Organ confined | Reference | Reference | ||||
| Extravesical | 3.60 | 2.44-5.29 | <0.001 | 2.40 | 1.50-3.84 | <0.001 |
| Variant histology of UC | ||||||
| Absent | Reference | Reference | ||||
| Present | 1.83 | 1.14-2.92 | 0.011 | 1.34 | 0.79-2.29 | 0.272 |
| LVI | ||||||
| Absent | Reference | Reference | ||||
| Present | 2.95 | 2.02-4.30 | <0.001 | 1.75 | 1.12-2.73 | 0.013 |
| Perivesical margin | ||||||
| Negative | Reference | Reference | ||||
| Positive | 3.54 | 1.54-8.11 | 0.003 | 1.10 | 0.45-2.68 | 0.833 |
| Pathologic nodal stage | ||||||
| N0 | Reference | Reference | ||||
| N1 | 2.93 | 1.72-4.99 | <0.001 | 2.32 | 1.33-4.06 | 0.003 |
| N2/N3 | 3.53 | 2.23-5.59 | <0.001 | 2.81 | 1.70-4.65 | <0.001 |
| No. of removed lymph nodes (continuous) | 0.95 | 0.93-0.98 | 0.001 | 0.95 | 0.92-0.97 | <0.001 |
| ACH | ||||||
| Not done | Reference | Reference | ||||
| Done | 1.65 | 1.11-2.44 | 0.012 | 0.75 | 0.46-1.21 | 0.241 |
HR, hazard ratio; CI, confidence interval; BMI, body mass index; Hb, hemoglobin; EBL, estimated blood loss; UC, urothelial carcinoma; LVI, lymphovascular invasion; ACH, adjuvant chemotherapy.