Supplementary Table 2. Univariate and multivariate Cox regression analyses results for evaluating variables associated with cancer-specific survival in patients receiving perioperative blood transfusions.
| Variable | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Unadjusted HR | 95% CI | p-value | Adjusted HR | 95% CI | p-value | |
| BMI (continuous) | 0.91 | 0.85-0.98 | 0.021 | 0.89 | 0.82-0.97 | 0.014 |
| Total transfused units (dichotomized) | ||||||
| ≤4 | Reference | |||||
| >4 | 1.13 | 0.70-1.82 | 0.595 | |||
| EBL (continuous) | 1.00 | 1.000-1.0001 | 0.001 | 1.00 | 1.00-1.00 | 0.002 |
| Pathologic tumor stage | ||||||
| Organ confined | Reference | Reference | ||||
| Extravesical | 3.79 | 2.39-6.01 | <0.001 | 1.48 | 0.84-2.61 | 0.173 |
| LVI | ||||||
| Absent | Reference | Reference | ||||
| Present | 4.17 | 2.64-6.59 | <0.001 | 3.16 | 1.92-5.20 | <0.001 |
| Perivesical margin | ||||||
| Negative | Reference | Reference | ||||
| Positive | 3.36 | 1.22-9.24 | 0.019 | 0.74 | 0.25-2.15 | 0.581 |
| Pathologic nodal stage | ||||||
| N0 | Reference | Reference | ||||
| N1 | 4.04 | 2.20-7.43 | <0.001 | 3.53 | 1.85-6.72 | <0.001 |
| N2/N3 | 5.33 | 3.18-8.96 | <0.001 | 4.61 | 2.56-8.32 | <0.001 |
| No. of removed lymph nodes (continuous) | 0.95 | 0.92-0.98 | 0.002 | 0.93 | 0.90-0.96 | <0.001 |
| NACH | ||||||
| Not done | Reference | Reference | ||||
| Done | 1.90 | 1.07-3.36 | 0.027 | 1.93 | 1.07-3.45 | 0.027 |
| ACH | ||||||
| Not done | Reference | Reference | ||||
| Done | 2.58 | 1.65-4.03 | <0.001 | 1.23 | 0.73-2.09 | 0.425 |
HR, hazard ratio; CI, confidence interval; BMI, body mass index; EBL, estimated blood loss; LVI, lymphovascular invasion; NACH, neoadjuvant chemotherapy; ACH, adjuvant chemotherapy.