Table 2.
Clinico-pathological characteristics between three groups
| variable | NBNC-HCC | HBV-HCC | HCV-HCC | p (vs HBV) | p (vs HCV) |
|---|---|---|---|---|---|
| Age | 70.44±8.77 | 61.89±10.54 | 69.20±7.52 | < 0.001a | 0.234a |
| Sex Man / Woman |
62(77.5%) / 18(22.5%) | 29(82.8%) / 6(17.2%) | 72(69.2%) / 32(30.8%) | 0.510b | 0.209b |
| Diabetes mellitus Yes / No |
32(40%) / 48(60%) | 7(20.0%) / 28(80.0%) | 30(28.8%) / 74(71.2%) | 0.032b | 0.113b |
| Body mass index | 25.15±3.61 | 23.36±2.92 | 23.71±3.51 | 0.011b | 0.007a |
| Alcohol consumption Yes / No |
30(37.5%) / 50(62.5%) | 12(34.3%) / 23(65.7%) | 24(23.1%) / 80(76.9%) | 0.741b | 0.034b |
| Hypertension Yes / No |
26(32.5%) / 54(67.5%) | 5(14.3%) / 30(85.7%) | 27(26.0%) / 77(74.0%) | 0.035b | 0.333b |
| Child-Pugh A / B, C |
69(86.2%) / 11(13.8%) | 32 (91.4%)/ 3(8.6%) | 72 (69.2%)/ 32(30.8%) | 0.421b | 0.016b |
| ICGR15, % | 15.75±9.11 | 14.87±8.56 | 21.30±11.40 | 0.628a | < 0.001a |
| AFP, ng/ml | 3519±12623 | 1679±450 | 1930±10214 | 0.404a | 0.349a |
| PIVKA II, mAU/ml | 4779±12792 | 9928±18879 | 3197±9681 | 0.091a | 0.341a |
| platelet, 104/μl | 17.31±6.57 | 15.75±7.25 | 13.25±6.25 | 0.250a | < 0.001a |
| Prothrombin time, % | 93.96±10.89 | 88.74±10.23 | 86.13±16.33 | 0.018a | < 0.001a |
| AST, IU/l | 40.97±20.77 | 38.26±21.76 | 53.09±21.57 | 0.528a | < 0.001a |
| ALT, IU/l | 37.54±21.54 | 34.26±18.32 | 50.73±28.84 | 0.434a | < 0.001a |
| T-Bil, mg/dl | 0.855±0.371 | 0.829±0.327 | 0.855±0.371 | 0.717a | 0.236a |
| Total protein, g/dl | 7.073±0.599 | 7.103±0.613 | 7.400±0.694 | 0.809a | < 0.001a |
| albumin, g/dl | 3.938±0.425 | 3.994±0.365 | 3.748±0.538 | 0.494a | 0.010a |
| Tumor size, cm | 5.69±4.17 | 4.27±3.32 | 3.03±2.14 | 0.079a | < 0.001a |
| Tumor numbers | 1.50±0.99 | 1.83±1.65 | 1.63±1.47 | 0.190a | 0.514a |
| Tumor stage I, II / III, IV |
37(46.3%)/43(53.7%) | 21(60.0%) / 14(40.0%) | 75(72.1%)/ 29(27.9%) | 0.173b | < 0.001b |
| Metastasis Yes / No |
5(6.3%) / 75(93.7%) | 2(5.7%) / 33(94.3%) | 7(6.7%) / 97(93.3%) | 0.684b | 0.753b |
| Pathological parameter | |||||
| Infiltraion to blood vessel Yes / No |
35(51.5%) / 33(48.5%) | 10(35.7%) / 18(64.3%) | 22(31.0%) / 49(69.0%) | 0.157b | 0.014b |
| Fibrosis 1, 2 / 3, 4 |
59(86.8%) / 9(13.2%) | 16(57.1%) / 12(42.9%) | 40(56.3%) / 31(43.7%) | < 0.001b | < 0.001b |
| Fatty liver Yes / No |
12(17.7%) / 56(82.3%) | 4 (14.3%) / 24(85.7%) | 4 (5.6%) / 67(94.4%) | 0.684b | 0.024b |
| Differentiation High / moderately / low |
11(16.2%) / 47(69.1%) / 10(14.7%) | 5(17.9%) / 21(75%) / 2(7.1%) | 16(22.5%) / 50(70.4%) / 5(7.1%) | 0.540b | 0.624b |
Data are presented as number, percent and median ± standard deviation, a; unpaired t-test, b; Fisher exact probability test