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Time scale of antibody titers of rabbits immunized by vaccine (0.25mg/kg) at the time points shown. Each point represents mean antibody titers (n = 6). Antibody titers were measured by an ELISA assay using a 1:100 dilution of antisera. Immunizations are indicated by arrows, *p < 0.05 vs 4 weeks, **p > 0.05 vs 4 weeks.
