Table 4.
The diagnosis efficiency of the conjoint analysis of tumor markers (HCC group versus non-HCC group).
| Items | AFU | AFP | TK1 | Combination |
|---|---|---|---|---|
| Optimal cut-off | 40.80 U/L | 10.86 μg/L | 1.92 pmol/L | – |
| Sensitivity (%) | 72.4 | 75.0 | 63.8 | 85.3 |
| Specificity (%) | 63.8 | 92.0 | 83.1 | 83.1 |
| Diagnostic accuracy (%) | 66.9 | 85.9 | 76.1 | 83.9 |
| Younden’s index (%) | 36.2 | 67.0 | 46.9 | 68.4 |
| SE | 0.029 | 0.028 | 0.028 | 0.019 |
| AUC (95% CI) | 0.718 (0.662–0.774) | 0.832 (0.778–0.887) | 0.773 (0.719–0.827) | 0.900 (0.863–0.937) |
| Z-value# | 5.379 | 2.010 | 3.753 | – |
| P-value# | <0.01 | <0.05 | <0.01 | – |
#
Comparing the area under ROC curve of combination to single tumor marker in HCC versus non-HCC. SE, standard error. AUC, area under the receiver operating characteristic.