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. 2014 Oct 17;22(5):731–742. doi: 10.1038/cdd.2014.164

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Copyright © 2015 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/

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FK866 delays Wallerian degeneration in vivo. (a) Schematic of larval zebrafish head indicating position of trigeminal neurons and axons, relative to the fish eye. (b) Time to beginning of fragmentation following laser axotomy in larvae pretreated for 2 h with vehicle (1% DMSO) (n=25), 50 μM (n=9), 200 μM (n=11) or 1 mM (n=10) FK866. Each circle represents one experiment; horizontal bar denotes average degeneration time (# indicates data from axon still intact >24 h, *P<0.05; **P<0.001). (c) Confocal images of trigeminal neurons postaxotomy labeled with DsRed-Express and treated with 1% DMSO or FK866. Arrowheads point to the site of axotomy. Scale bar, 100 μm