Table 1.
Differences between the 3 FTO genotypes and Clinical/ paraclinical parameters and obesity associated disorders
| MEASURE | HmWt (15/53, 28.3%) | Ht (20/53, 37.74%) | HmMut (18/53, 33.96%) | P value ANOVA |
|---|---|---|---|---|
| Weight (kg) | 60.20 ± 15.76 (36.00 – 87.00) | 81.40 ± 28.52 (35.00 – 130.00) | 112.28 ± 35.16 (65.0 – 191.0) | 0.000 |
| Abdominal circumrence (cm) | 77.27 ± 11.63 (62.00 – 107.0) | 95.45 ± 30.13 (59.00 – 199.00) | 111.67 ± 30.01 (68.0 – 180.0) | 0.002 |
| BMI (kg/cm2) | 23.37 ± 3.98 (19.20 – 32.70) | 30.33 ± 7.52 (20.03 – 45.90) | 37.88 ± 9.43 (21.90 – 55.10) | 0.000 |
| BMR (calories) | 1500.40 ± 208.23 (1173.00 – 1903.60) | 1706.19 ± 379.74 (1189.20 – 2495.40) | 1983.01 ± 568.30 (1135.40 – 3206.10) | 0.007 |
| Total caloric needs (calories) | 2063.06 ± 286.31 (1612.88 – 2617.45) | 2346.02 ± 522.14 (1635.15 – 3431.18) | 2726.64 ± 781.41 (1561.18 – 4408.39) | 0.007 |
| Body.fat.percentage (%) | 14.55 ± 9.23 (0.47 – 33.72) | 19.08 ± 10.76 (-5.64 – 34.30) | 27.87 ± 9.67 (6.63 – 50.41) | 0.001 |
| Body fat mass (kg) | 9.49 ± 7.64 (0.17 – 29.34) | 17.97 ± 12.14 (-1.97 – 41.38) | 32.14 ± 18.53 (4.71 – 76.62) | 0.000 |
| Excess body fat mass (kg) | 3.48 ± 6.61 (-4.26 – 20.64) | 9.83 ± 10.03 (-5.47 – 32.38) | 21.05 ± 15.66 (-2.39 – 61.42) | 0.000 |
| Fasting glucose (mg/dl) | 87.66 ± 6.88 (73.00 – 101.00) | 94.40 ± 10.90 ± 75.00 – 112.00 | 117.22 ± 26.59 (90.0 – 175.0) | 0.000 |
| Systolic blood pressure (mmHg) | 113.73 ± 4.36 (105.0 – 120.0) | 136.5 ± 23.85 (110.0 –193.0) | 152.16 ± 30.6 (110.0 – 210.0) | 0.000 |
| Diastolic blood pressure (mmHg) | 73.40 ± 4.06 (67.00 – 80.00) | 87.20 ± 18.77 (68.0 – 146.0) | 86.11 ± 15.99 (60.0 – 130.00) | 0.020 |
| TSH (µU/ml) | 3.22 ± 1.16 (1.74 – 6.42) | 3.67 ± 2.52 (1.50 – 12.30) | 3.19 ± 1.76 (1.10 – 7.52) | 0.700 |
| Total cholesterol (mg/dl) | 167.33 ± 27.56 (133 – 205) | 194.75 ± 48.00 (129 – 290) | 220.67 ± 40.34 (135 – 303) | 0.002 |
| LDL-cholesterol (mg/dl) | 105.27 ± 21.71 (72 – 150) | 124.65 ± 36.46 (69 – 200) | 152.06 ± 33.23 (80 – 200) | 0.000 |
| HDL-cholesterol (mg/dl) | 37.93 ± 10.97 (27 – 73) | 42.45 ± 19.75 (24 – 120) | 39.66 ± 9.64 (30 – 64) | 0.653 |
| Triglycerides (mg/dl) | 108.67 ± 39.50 (36 – 208) | 127.60 ± 51.02 (58 – 220) | 164.28 ± 39.10 (103 – 225) | 0.002 |
| AST (GOT) (U/l) | 25.46 ± 8.36 (13.00 – 41.00) | 30.20 ± 18.54 (10.0 – 72.00) | 30.87 ± 19.34 (10.00 – 85.00) | 0.608 |
| ALT (GPT) (U/l) | 27.46 ± 10.22 (12.0 – 49.00) | 47.15 ± 41.49 (12.0 – 131.0) | 42.74 ± 38.19 (12.0 – 145.00) | 0.235 |
| Obesity* (N) (34/53, 65.15%) | 3/15, 20 % | 14/20, 70 % | 17/18, 94.44 % | 0.000 |
| Hyperglicemia** (N) (31/53, 58.49%) | 1/15, 6.67 % | 16/20, 80 % | 14/18, 77.78 % | 0.000 |
| Diabetes mellitus (N) (9/53, 16.98%) | 0/15, 0 % | 1/20, 5 % | 8/14, 44.44 % | 0.066 |
| Hypertension (N)(21/53, 39.62%) | 0/15, 0 % | 10/20, 50 % | 11/18, 61.11 | 0.000 |
| Hypothyroidism (N) (4/53, 7.55%) | 0/15, 0 % | 3/20, 15 % | 1/18, 5.56 % | 0.243 |
| Dyslipidemia (N) (26/53, 49.05%) | 3/15, 20 % | 9/20, 45 % | 14/18, 77.78 % | 0.003 |
| Hypercolesterolemia (N) (26/53, 49.05%) | 3/15, 20 % | 9/20, 45 % | 14/18, 77.78 % | 0.003 |
| Hypertriglyceridemia (N) (19/53, 35.85%) | 1/15, 6.67 % | 6/20, 30 % | 12/18, 66.67 % | 0.001 |
| Metabolic syndrome (N) (23/53, 43.39%) | 2/15, 13.33 % | 8/20, 40 % | 13/18, 72.22 % | 0.002 |
| Hepatic steatosis (N) (10/53, 18.87%) | 0/15, 0 % | 5/20, 25 % | 5/18, 27.78 % | 0.088 |
| N = no. of cases;* overweight/ obese; ** impaired glucose tolerance/ diabeste mellitus |