Key changes in lipoprotein metabolism in type 2 diabetes
Lipoprotein	Quantitative changes	Qualitative changes	Kinetic/metabolic changes
Chylomicron	• Increased plasma concentration	• Very few data (decreased ApoE content in diabetic rabbits)	• Increased production • Decreased catabolism
VLDL	• Increased plasma concentration	• Greater proportion of larger particles (VLDL1) • Increased palmitic acid-containing species and diacylglycerol, reduced sphingomyelin • Glycation	• Increased production • Decreased catabolism
LDL	• No change or slightly increased plasma concentration	• Greater proportion of small, dense particles (triacylglycerol enrichment) • Increased LDL oxidation • Increased palmitic acid-containing species and diacylglycerol, reduced sphingomyelin • Glycation	• Decreased catabolism
HDL	• Decreased plasma concentration	• Triacylglycerol enrichment • Reduced phospholipids, ApoE and ApoM • Glycation	• Increased catabolism