Table 3.
Diagnostic accuracy of 11q13 amplification for nodal status in OSCC
| Study | Nodal metastasisa | Threshold for amplification | Amplification | OR (95 % CI) | p value | NPV (%) | PPV (%) | AC (%) | SE | SP |
|---|---|---|---|---|---|---|---|---|---|---|
| Hanken et al. | 117/255, 46 % | G/C ratio >2.0 | 69/255, 27 % | 1.66 (0.95–2.90) | 0.074 | 57 | 55 | 57 | 32 | 77 |
| Yoshioka et al. | 15/25, 60 % | G/C ratio >1.12 | 13/25, 52 % | 1.14 (0.23–5.67) | 0.870 | 42 | 62 | 52 | 53 | 50 |
| Sugahara et al. | 22/54, 41 % | G/C ratio >1.5 in ≥3 genes | 14/54, 26 % | 5.83 (1.52–22.33) | 0.010 | 70 | 71 | 70 | 45 | 88 |
| Pathare et al. | 54/97, 56 % | G/C ratio >1.25 | 40/97, 41 % | 1.35 (0.60–3.06) | 0.473 | 47 | 60 | 53 | 44 | 63 |
| Michikawa et al. | 53/127, 42 % | G/C ratio >1.2 and gene/cell ratio >3 | 43/127, 34 % | 2.78 (1.30–5.92) | 0.008 | 67 | 58 | 64 | 47 | 76 |
| Mahdey et al. | 27/50, 54 % | G/C ratio >2.0 | 36/50, 72 % | 1.87 (0.54–6.51) | 0.327 | 57 | 58 | 58 | 78 | 35 |
| Prapinjumrune et al. | 13/30, 43 % | G/C ratio >1.5 | 13/30, 43 % | 0.70 (0.16–3.05) | 0.638 | 53 | 38 | 47 | 38 | 53 |
| Myo et al. | 17/45, 38 % | >20 % of 100 cells ≥3 spots | 15/45, 33 % | 20 (4.09–97.90) | <0.001 | 83 | 80 | 82 | 71 | 89 |
| Fujii et al. | 14/23, 61 % | >20 % of 100 cells ≥3 spots | 13/23, 57 % | 0.50 (0.09–2.84) | 0.434 | 30 | 54 | 43 | 50 | 33 |
OR odds ratio, CI confidence interval, G/C gene/chromosome, NPV negative predictive value, PPV positive predictive value, AC accuracy, SE sensitivity, SP specificity
aHistologically proven nodal metastasis