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. 2014 Jan 21;74(5):818–822. doi: 10.1136/annrheumdis-2013-204427

Figure 2.

Figure 2

(A) Proportions of patients responding to pneumococcal serotype combinations from ≥1 to ≥12. Tocilizumab 8 mg/kg+methotrexate (tocilizumab (TCZ)+methotrexate (MTX); n=54) versus methotrexate (MTX; n=27). In this secondary end point analysis, the results show that, overall, a greater proportion of MTX-treated patients responded to serotype combinations. Error bars represent the 95% CIs, which indicate a notable degree of variation. (B) Proportions of patients responding to individual pneumococcal antigen serotypes. TCZ+MTX (n=54) versus MTX (n=27). In this secondary end point analysis, the results show that the proportion of responders to serotypes 3, 4, 7f, 12f, 14 and 23f was comparable (<10% difference) between that of the TCZ+MTX and MTX treatment groups, whereas the proportion of responders to serotypes 1, 6b, 8, 9n, 18c and 19f was lower in the TCZ+MTX treatment group than in the MTX treatment group (>10% difference). For serotypes 9n and 12f: MTX, n=23; for serotype 14: MTX, n=21; for serotypes 1, 3, 7f, 8 and 12f: TCZ+MTX, n=49.