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. 2014 Jun 20;64(4):636–645. doi: 10.1136/gutjnl-2013-306620

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Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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Identification of somatic mutations by exome sequencing in 22 patients with CRC for genomic discovery. (A) Spectrum of nucleotide alterations was determined in each exome-sequenced patient with CRC. Nucleotide change was predominated by C/G>T/A transition. (B) The landscape of non-silent mutations at genome-wide scale was depicted with the height of each gene reflecting the mutation frequency among 22 patients with CRC. Three reported gene mountains (ie, APC, KRAS, TP53) were interspersed with many novel gene hills (eg, FAT4, NF1, DOCK2, HERC2) discovered in our CRC cohort.