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. 2014 Jun 20;64(4):636–645. doi: 10.1136/gutjnl-2013-306620

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This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 3.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/3.0/

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Signalling pathways genetically altered in CRC. (A) Significantly mutated pathways with positive selection of non-silent mutations were ranked by Q-score. (B) Mutation frequencies of individual signalling components of four major signalling pathways, namely, Wnt signalling, ErbB signalling, transforming growth factor-β signalling and DNA damage sensing/repair, in 182 patients with CRC were shown. These pathways exhibited genetic alteration in a majority (50–65%) of CRC samples.