Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2014 Jul 11;64(4):618–626. doi: 10.1136/gutjnl-2014-306834

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions

This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 3.0) license, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: http://creativecommons.org/licenses/by/3.0/

PMC Copyright notice

(A) Human ascending colonic mucosa was stimulated with 25 and 50 mmol/L Phe/Trp or high calcium Krebs as control. There was a significant increase in the number of pCamKII-IR cells following stimulation at both concentrations (*p<0.05) compared with control. pERK-IR was not induced (not shown). Scale bar 15 μm. (B) In human colon, Phe/trp at 25 mmol/L resulted in specific activation of 5-HT-IR pCaMKII cells, while GLP-1 cells were not found to colocalise with pCamKII. 5-HT-IR and GLP-IR were found predominantly in the basolateral membrane (insets), suggesting that the peptide was located in vesicles in anticipation of release following CaSR stimulation. Scale bar 15 μm. (C) Effect of lauric acid (12.5 and 25 mmol/L) on pERK-IR in sheets of human proximal colonic mucosa. There was a concentration-dependent increase in the number of IR cells with increasing concentrations (*p<0.05) compared with control. Scale bar 15 μm.