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Model of CpsABCD involvement in CPS biosynthesis. A, topology and subcellular localization of the CpsABCD proteins and of the CpsH polymerase was predicted using PSORTb and Octopus. The repeating unit (RU), the capsular polysaccharide (CPS), and the cell wall peptidoglycan (PG) are also represented. B, schematic representation of the working model proposed for the CpsABCD proteins. Arrows, enzymatic reactions; bar-headed line, an inhibitory effect; dotted line, an interdependency.
