FIGURE 6.

Schematic of transporter modulation by lipid bilayer composition. A, Glt_Ph reconstituted in liposomes orients as either the RSO or ISO transmembrane orientation, and these two populations have different K_0.5 values for aspartate transport. The transport domain is represented in blue, and the trimerization domain is colored wheat. B, movements of the trimerization domain into the surrounding lipid bilayer are made more or less favorable (arrow thickness) depending on the amino acid residue present at position 33. Movement of the trimerization domain into the surrounding lipid bilayer is required for transport.