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Che-1/AATF is a central mediator of the cellular response to different types of stress. In response to DNA damage and cellular stress Che-1/AATF promotes cell survival by inducing cell cycle arrest, autophagy, DNA repair and inhibition of apoptosis. Otherwise if DNA damage is too severe Che-1/AATF is degradated and cells undergo apoptosis. ER, endoplasmatic reticulum.
