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. Author manuscript; available in PMC: 2016 Jan 31.
Published in final edited form as: Circ Cardiovasc Genet. 2015 Feb;8(1):64–73. doi: 10.1161/HCG.0000000000000022

Figure 2.

Figure 2

Current recordings of SCN10A variants. A) Representative whole-cell current traces of Nav1.8, using V1073 as reference construct, and mutant channels. Currents were recorded following a voltage step protocol with 5 mV increments from −70 mV to +50 mV, preceded with a −100 mV step. B) Current-voltage (I-V) relationship. The current is normalized to cell capacitance to provide a measure of Na+ current density. C) Peak current density at 15mV, Two-way ANOVA with Bonferroni post-tests was applied to test for significant differences. Mean ± SEM values are presented in Table 4. B, C) n=13–15 for each group. Asterisks indicate the voltages at which the parameters were statistically different versus V1073 *p<0.05, **p<0.01 and ***p<0.001.