Table 1.

Clinical characteristics of the lone AF patients with rare variants (MAF < 0.5% in EA in ESP6500)

Patients	Exon	rs ID	Pos. of variants	ECG description	P-wave (ms)	PR interval (ms)	QRS interval (ms)	QTc (ms)	HR (bpm)	Type of AF	Onset of AF	Clinical information	rs6795970 (A1073)	rs12632942 (P1092)
1	E1	rs141207048	R14L	SR	135	206	98	434	112	Paroxysmal	31	AVNRT	V/A	L/P
2	E2	rs202143516	V94G	SR	119	144	102	414	57	Paroxysmal	28	Father and sister pacemaker	V/A	L
3	E2	rs202143516	V94G	SR	94	132	84	396	64	Paroxysmal	31	Nonhemorragic stroke after AF diagnosis	V/A	L
4	E4 E15	rs202192818 rs139861061	Y158D R814H	SR, SVPCs with aberration	131	186	86	418	103	Persistent	32	AF RFA times four	V/A	L/P
5	E4	rs75991777	c.599+1	SR	135	162	116	421	63	Paroxysmal	35	Atrial flutter, AVNRT, inducible VT and ICD. Normal coronary angiography. Family history of SCD and AF.	A	L
6	E15	rs146028829	E825D	SR	110	172	72	423	84	Paroxysmal	18	AF RFA, AVNRT	V/A	L/P
7	E16	unknown	I999L	SR, IRBBB	118	160	100	412	61	Paroxysmal	35	Mother with SVPCs	V/A	L
8	E21	rs138832868	R1268Q	SR, IRBBB	90	152	94	394	59	Paroxysmal	30	Several DC cardioversions	A	L/P
9	E21	rs138832868	R1268Q	AF	-	-	92	-	96	-	23	Atrial flutter type II	A	L/P
10	E26	rs142217269	C1523Y	SR, J-wave in II, III, aVF	119	154	96	398	54	Paroxysmal	30	Family history of AF	A	L
11	E27	unknown	R1588Q	SR	110	156	96	419	55	Paroxysmal	28	RFA for AVNRT	A	L/P

Positions and clinical characteristics of the patients with rare variants with minor allele frequencies (MAF) less than 0.5% in the European-American (EA) in the Exome Sequencing Project (n=6503, ESP6500) server. SR; Sinus rhythm, SVPC; Supraventricular premature complexes, IRBBB; Incomplete right bundle branch block, AF; Atrial fibrillation, AVNRT; AV-nodal reentry tachycardia, RFA; Radiofrequency ablation, ICD; Implantable cardioverter-defibrillator, VT; Ventricular Tachycardia