. 2015 Mar 13;4(3):e001264. doi: 10.1161/JAHA.114.001264

Table 5.

Relationship of BMI to LV Structural and Functional Parameters at the Year‐25 Examination

	n	R ²	Year‐25 BMI	Year‐0 BMI
	n	R ²	β (SE)	β (SE)
Structural indices
LVEDV/height, mL/m
Model 1	3078	0.23	0.68 (0.04)^*
Model 2	3078	0.25	0.73 (0.04)^*
Model 3	3078	0.27	0.52 (0.06)^*	0.42 (0.08)^*
LVM/height, g/m
Model 1	2980	0.33	1.89 (0.07)^*
Model 2	2980	0.37	1.76 (0.07)^*
Model 3	2980	0.39	1.27 (0.09)^*	1.04 (0.13)^*
Systolic indices
LVEF, %
Model 1	3077	0.03	−0.05 (0.02)^*
Model 2	3077	0.04	−0.06 (0.02)^*
Model 3	3077	0.04	−0.01 (0.03)	−0.10 (0.04)
Ell, %
Model 1	2908	0.10	0.06 (0.01)^*
Model 2	2908	0.15	0.04 (0.01)^*
Model 3	2908	0.16	0.04 (0.01)^*	−0.01 (0.01)
Diastolic indices
E/e' ratio
Unadjusted	3239	0.05
Model 1	3239	0.10	0.06 (0.01)^*
Model 2	3239	0.17	0.05 (0.01)^*
Model 3	3239	0.18	0.05 (0.01)^*	−0.003 (0.01)
Ell_SRe, sec⁻¹
Unadjusted	2896	0.06
Model 1	2896	0.09	−0.01 (0.001)^*
Model 2	2896	0.12	−0.001 (0.001)^*
Model 3	2896	0.12	−0.0003 (0.001)	−0.003 (0.001)

Model 1 is adjusted for race–ethnicity and sex group, age, and BMI at Year‐25. Model 2 is further adjusted for Model 1+Year‐25 risk factors (educational level, physical activity, heart rate, presence of diabetes, systolic blood pressure, diastolic blood pressure, use of antihypertensive medications, and number of cigarettes/day). Model 3 is further adjusted for Model 2+Year‐0 risk factors (BMI, educational level, physical activity, heart rate, presence of diabetes, systolic blood pressure, diastolic blood pressure, use of antihypertensive medications, and number of cigarettes/day). BMI indicates body mass index; E/e', ratio of mitral early peak velocity/mitral annulus early peak velocity; Ell, longitudinal peak systolic strain; Ell_SRe, longitudinal peak early diastolic strain rate; LV, left ventricular; LVEDV, LV end‐diastolic volume; LVEF, left ventricular ejection fraction; LVM, LV mass.

P<0.05.