Table 1.
iTTR Summary Statistics for Each Method of INR Imputation, Overall and by Geographic Region
| Region | iTTR Statistic | Imputation Method: | ||||
|---|---|---|---|---|---|---|
| 1.a. Assuming Dose Change After Any OOR <2 or >3 | 1.b. Assuming Dose Change After Any OOR <1.8 or >3.2 | 2.a. Using Dose Data With OOR <2 or >3 | 2.b. Using Dose Data With OOR <1.8 or >3.2 | 3. Rosendaal | ||
| All regions (N=6983) | Mean (SD) | 58.3 (22.2) | 57.6 (21.7) | 55.9 (21.7) | 56.0 (21.6) | 55.2 (21.3) |
| Median (IQR) | 62.0 (46.3, 74.6) | 61.1 (46.0, 73.5) | 58.9 (43.3, 71.8) | 58.9 (43.9, 71.8) | 57.9 (43.0, 70.6) | |
| East Asia (n=727) | Mean (SD) | 54.0 (22.3) | 53.3 (22.0) | 51.3 (22.0) | 51.5 (22.0) | 50.4 (21.4) |
| Median (IQR) | 58.2 (40.6, 70.0) | 56.8 (39.3, 68.9) | 55.0 (37.4, 67.0) | 55.3 (38.2, 67.0) | 53.1 (37.6, 64.8) | |
| India (n=130) | Mean (SD) | 37.4 (26.0) | 37.3 (25.6) | 36.2 (24.9) | 36.4 (24.7) | 35.9 (23.3) |
| Median (IQR) | 36.2 (15.9, 56.1) | 36.9 (15.0, 57.4) | 34.9 (15.0, 54.5) | 35.6 (15.0, 54.5) | 36.7 (18.6, 50.7) | |
| Eastern Europe (n=2663) | Mean (SD) | 52.6 (22.5) | 52.1 (22.0) | 50.5 (21.9) | 50.7 (21.7) | 49.7 (21.2) |
| Median (IQR) | 55.8 (38.9, 68.8) | 55.2 (39.2, 67.8) | 52.9 (37.0, 66.2) | 53.2 (37.6, 66.3) | 51.9 (36.8, 64.7) | |
| Western Europe and similar (n=1088) | Mean (SD) | 67.0 (18.6) | 65.9 (18.3) | 64.1 (18.6) | 64.1 (18.5) | 63.2 (18.5) |
| Median (IQR) | 70.5 (58.4, 79.3) | 69.0 (57.3, 77.9) | 66.6 (55.2, 77.0) | 66.6 (55.2, 76.6) | 66.1 (53.7, 75.9) | |
| South Africa (n=124) | Mean (SD) | 58.8 (22.6) | 57.8 (22.1) | 55.1 (22.6) | 55.0 (22.5) | 54.8 (22.1) |
| Median (IQR) | 63.6 (47.8, 74.8) | 61.3 (46.6, 74.2) | 58.3 (42.7, 72.9) | 58.2 (42.9, 72.9) | 57.3 (42.9, 70.6) | |
| Latin America (n=924) | Mean (SD) | 58.0 (21.3) | 57.5 (20.8) | 55.8 (20.5) | 55.9 (20.3) | 55.2 (20.0) |
| Median (IQR) | 61.2 (47.5, 73.6) | 60.5 (47.2, 72.9) | 58.5 (45.0, 70.5) | 58.8 (45.0, 70.7) | 58.0 (44.5, 69.3) | |
| Canada/USA (n=1327) | Mean (SD) | 67.1 (18.4) | 66.2 (18.1) | 64.7 (18.3) | 64.6 (18.2) | 64.1 (18.2) |
| Median (IQR) | 69.9 (58.0, 80.0) | 68.9 (57.4, 78.7) | 66.9 (55.6, 77.3) | 66.9 (55.4, 77.4) | 66.3 (54.8, 77.0) | |
iTTR is given as percent. INR indicates international normalized ratio; iTTR, individual patient time in the therapeutic range; OOR, out of range.