Table 1.
Body Weight, Heart Rate, Urine Volume, Creatinine Clearance, and Plasma Parameters of Wt and rATRAP‐Tg Mice
| Variable | Wt | rATRAP‐Tg | ||
|---|---|---|---|---|
| NS (n=8) | HS (n=7) | NS (n=7) | HS (n=7) | |
| Body weight, g | 23.3±0.8 | 23.0±0.9 | 23.0±0.7 | 22.5±0.9 |
| Heart rate, bpm | 535±9 | 524±25 | 522±12 | 524±14 |
| Urine volume, μL/day per gram of body weight | 60±7 | 152±8* | 82±20 | 196±34* |
| Creatinine clearance, μL/min | 385±25 | 356±16 | 428±26 | 405±30 |
| Plasma concentrations | ||||
| Sodium, mEq/L | 151±1.2 | 150±0.8 | 152±1.6 | 150±0.6 |
| Potassium, mEq/L | 5.4±0.2 | 5.3±0.2 | 5.6±0.2 | 5.5±0.2 |
| Chloride, mEq/L | 111±0.8 | 110±0.7 | 110±1.0 | 111±0.4 |
| Calcium, mg/dL | 8.2±0.1 | 8.4±0.1 | 8.3±0.3 | 8.5±0.1 |
| Blood urea nitrogen, mg/dL | 27.5±1.9 | 31.5±1.7 | 25.3±1.8 | 27.4±1.7 |
| Creatinine, mg/dL | 0.08±0.01 | 0.10±0.01* | 0.08±0.01 | 0.09±0.01 |
| Aldosterone, pg/mL | 394±69 | 93±8* | 489±42 | 190±28* |
| Osmolality, mOsm/L | 329±2 | 337±2* | 331±3 | 345±5* |
All values are mean±SEM. Bpm indicates beats per minute; HS, high salt; NS, normal salt; rATRAP‐Tg, renal angiotensin II type 1 receptor associated protein transgenic; Wt, wild type.
*
P<0.05, vs NS, unpaired t test.
*
P<0.01, vs NS, unpaired t test.