Table 2.

HPV status and clinico-pathological parameters

	HR-HPV-	HR-HPV+	p-value*
Histopathologic subtype
keratinizing	38	15
basaloid	3	2	0.62
Grading
Low-grade (G1-2)	32	11
High-grade (G3-4)	9	6	0.33
Presence of tumour invasion
Non-invasive	5	7
Invasive	36	10	0.028
Presence of metastasis
N0M0	10	5
N+ and/or M+	11	2	0.40
p16 INK4a immunostaining
negative	24	0
scattered	10	0
intense nuclear/confluent	7	17	<0.001

*Fisher’s exact Test.