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. 2015 Apr 8;15:239. doi: 10.1186/s12885-015-1210-4

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© Larsen et al.; licensee BioMed Central. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Aurora kinases are important for growth of tamoxifen resistant cell lines. Parental and tamoxifen resistant T47D cell lines (TR-1 and TR-2) were treated for 5 days with the indicated concentrations of barasertib (A) and parental, fulvestrant and tamoxifen resistant T47D cell lines were treated with JNJ-7706621 (BandC). Cell number was determined by a crystal violet colorimetric assay and expressed as percent of untreated control. The experiments were performed twice with six sample replicates. Representative experiments with mean ± SD are shown. *P < 0.05 for barasertib or JNJ-7706621 treated samples vs. control.