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. 2015 Apr 1;15:36. doi: 10.1186/s12935-015-0183-3

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© Hu and Lu; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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The RNA (A, C) and protein (B, D) expression levels of MMP9 and MMP13 were both downregulated by BCYRN1 inhibition, and upregulated by BCYRN1 mimics. siRNA-NC: siRNA negative control; siRNA-1: siRNA-BCYRN1-1; siRNA-2: siRNA-BCYRN1-2; NC: negative control for BCYRN1 mimics, only treated with Lipofectamine 2000. * p < 0.01, indicated a significant difference; ** p < 0.01, indicated a very significant difference, compared with negative control.