Figure 2. WT and Atg16L1^HM mice display similar bacterial burden during S. aureus infection.

(A–K) Bacterial burden was quantified in the indicated organs and blood harvested from WT and Atg16L1^HM mice injected i.v. with 10⁷ cfu USA300 on days 3, 4, and 7 post infection. Data points represent bacterial burden in individual mice, bars represent median, and dashed line represents limit of detection. n=8–13 mice/condition. No significant differences in bacterial burden were noted when comparing the same organ from WT and Atg16L1^HM mice except when comparing cecal contents on day 7 (H). Statistical analyses were performed by ANOVA with the Kruskal-Wallis test and Dunn’s correction. Each time point represents data pooled from 2–3 independent repeats.