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Mean ΔG of binding during the MD trajectory and experimental SV2A binding data (see text for references).
| Ligand | ΔG (kcal/mol, Mean ± SD) | Experimental SV2A pKd |
|---|---|---|
| Levetiracetam | -5.60 ± 0.24 | 6.1 |
| Brivaracetam | -6.50 ± 0.31 | 7.2 |
| Seletracetam | -6.08 ± 0.41 | 7.1 |
| UCB30889 | -8.46 ± 0.32 | 7.6 |
