Table 3.

Urinary Excretion of Deuterated Glucocorticoid Metabolites During d4-cortisol Infusion

Metabolites, ng	Carbohydrate	Protein	Fat	Placebo
d4-5β-THF	322 ± 67	246 ± 51	343 ± 68	256 ± 50
d3-5β-THF	253 ± 59	198 ± 42	272 ± 54	205 ± 42
d4-5α-THF	134 ± 39	111 ± 24	143 ± 32	87 ± 22
d3-5α-THF	114 ± 35	97 ± 23	121 ± 28	75 ± 20
d3-5β-THE	345 ± 150	218 ± 65	318 ± 94	216 ± 39
Total deuterated tetrahydrometabolites	1168 ± 315	869 ± 161	1197 ± 195	839 ± 94
d4-Cortisol	7 ± 1	6 ± 1	5 ± 1	4 ± 2
d3-Cortisol	15 ± 2	21 ± 8	14 ± 3	10 ± 2
d3-Cortisone	109 ± 27	74 ± 17	100 ± 24	132 ± 20

Data are mean ± SEM for urinary excretion of deuterated 5β-THF, 5α-THF, 5β-THE, and urinary free deuterated cortisol and cortisone after high-carbohydrate, -protein, -fat, and -placebo meals (n = 8 all groups). Urinary deuterated metabolites were summed from samples collected at t + 270, t + 330, and t + 390 min time points. There were no differences in excretion of any deuterated metabolites between diets either before or after the meals.