Table 5.
Odds ratios for association between cotton and wool dust ever exposure and lung cancer in two studies in Montreal, stratified by histological type of lung cancer
| Exposure group | Study 1 | Study 2 | Pooled | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Population controls | Cancer controls | All controls, weighted | Males | Females | Population controls | |||||
| na | ORb(95% CI) | OR (95% CI) | OR (95% CI) | n | OR (95% CI) | n | OR (95% CI) | n | OR (95% CI) | |
| Cotton dust | ||||||||||
| Squamous | 23 | 1.2 (0.6-2.3) | 0.8 (0.5-1.3) | 1.0 (0.6-1.6) | 37 | 1.3 (0.8-2.0) | 19 | 0.9 (0.4-1.7) | 79 | 1.1 (0.8-1.5) |
| Small cell | 7 | 0.8 (0.3-2.2) | 0.6 (0.2-1.0) | 0.7 (0.3-1.5) | 16 | 1.2 (0.6-2.5) | 30 | 1.1 (0.5-2.3) | 53 | 1.2 (0.8-1.8) |
| Adenocarcinoma | 21 | 2.7 (1.4-5.3) | 1.7 (1.0-2.9) | 2.1 (1.2-3.7) | 46 | 1.9 (1.2-3.0) | 61 | 1.2 (0.7-1.8) | 128 | 1.6 (1.2-2.2) |
| Wool dust | ||||||||||
| Squamous | 14 | 1.1 (0.5-2.4) | 0.6 (0.3-1.2) | 0.8 (0.4-1.6) | 13 | 0.6 (0.3-1.3) | 6 | 0.7 (0.3-2.2) | 33 | 0.8 (0.5-1.2) |
| Small cell | 7 | 1.1 (0.4-3.2) | 0.8 (0.4-1.9) | 1.0 (0.4-2.3) | 6 | 0.8 (0.3-2.0) | 7 | 0.8 (0.3-2.6) | 20 | 0.9 (0.5-1.6) |
| Adenocarcinoma | 12 | 2.2 (1.0-4.9) | 1.3 (0.7-2.5) | 1.6 (0.8-3.2) | 22 | 1.4 (0.8-2.5) | 24 | 1.2 (0.6-2.4) | 58 | 1.4 (1.0-2.0) |
a n = number of exposed cases.
b OR refers to odds ratio, adjusted for: age, ethnicity (French Canadian or other), years of education (0-7, 8-12 or 13+), familial financial situation during childhood (difficult, intermediate or comfortable), proxy respondent (yes or no), cumulative smoking index (CSI), and any occupational exposure to asbestos, chromium, nickel or silica. Pooled results are additionally adjusted for study.