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. Author manuscript; available in PMC: 2015 Apr 10.
Published in final edited form as: Circ Res. 2013 Nov 5;114(2):257–265. doi: 10.1161/CIRCRESAHA.114.302734

Figure 1. Cardiac RNA transcript levels of Parkin pathway factors and Parkin-related E3 ubiquitin ligases in Parkin knockout (KO) mice.

Figure 1

A and B, Volcano plot (A) and heat maps (B) of cardiac transcriptional changes induced by germline Parkin gene ablation in mice. C, Gene ontology analysis of up- (top) and downregulated mRNAs in Parkin KO mouse hearts. D, mRNA levels of Parkin and upstream Parkin signaling factors PINK1 and Mfn2; Mfn1 is shown for comparison. E, Transcript levels of Parkin-related E3 ubiquitin ligases of RING2, RING1, and in-between ring families. Gene names are: Arih1, ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein 1; Arih2, ariadne homolog 2; Cul9, cullin 9; Rnf, ring finger protein; Rbck1, RanBP-type and C3HC4-type zinc finger containing 1; Cyhr1, cysteine/histidine-rich 1; Rbx1, ring-box 1; Mib2, mindbomb homolog 2; Polr3k, polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa. Values are mean±SEM of RNA sequencing reads per million bases (RPKM) for n=5 wild type (WT) and n=4 germline Parkin null (KO) mice.