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. 2015 Jan 26;4:24. [Version 1] doi: 10.12688/f1000research.6075.1

Figure 1. Systemic lupus erythematosus is a heterogeneous group of multifactorial diseases.

Figure 1.

The development of lupus is influenced by genetic factors, controlling individual variability especially with regard to the immune system and also with regard to physiology. Anatomical features may determine organ damage and source of autoantigens. Environmental factors can act upon all these elements, and may be the component we could try to modulate with the aim of preventing disease development. SLE, systemic lupus erythematosus; BCR, B-cell antigen receptor; TCR, T-cell antigen receptor; ECM, extracellular matrix; FcγR, Fc receptor for IgG.