Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	222 Vietnamese children, aged 1–15 years with dengue shock syndrome	Fever and chills 0 children with crystalloid regimens (sodium chloride or Ringer’s lactate) 6 children with colloid regimens (dextran 70 or gelafundin)	Significance not reported
RCT	222 Vietnamese children, aged 1–15 years with dengue shock syndrome	Recurrence of shock 0 children with crystalloid regimens (sodium chloride or Ringer’s lactate) 2 children with colloid regimens (dextran 70 or gelafundin)	Significance not reported A total of 35 children equally distributed among the four groups required diuretic treatment for 1 or 2 days after recovery from shock
RCT	222 Vietnamese children, aged 1–15 years with dengue shock syndrome	Bleeding 0 children with crystalloid regimens (sodium chloride or Ringer’s lactate) 2 children with colloid regimens (dextran 70 or gelafundin)	Significance not reported 1 child receiving gelafundin had severe epistaxis requiring transfusion, while 1 child receiving dextran developed a large haematoma at a site of minor trauma
RCT 3-armed trial	383 Vietnamese children aged 2–15 with moderately severe dengue shock syndrome (moderate severity: pulse pressure >10 mmHg and up to 20 mmHg)	Allergic type reactions 0/128 (0%) with Ringer’s lactate (crystalloid regimen) 9/126 (7%) with 6% dextran 70 (colloid regimen) 1/129 (1%) with 6% hydroxyethyl starch (colloid regimen)	Difference among groups P < 0.001 Of the additional 129 children in the RCT with severe shock, allergic reactions were reported in 6/67 [9%] with dextran v 0/62 [0%] with starch; P = 0.03 Overall in the RCT, 15 children receiving dextran had severe reactions (transient high fever and rigors without cardiorespiratory compromise) that occurred within 6 hours of infusing the study fluid, and 1 child in the starch group developed an urticarial rash without fever at the end of the infusion All children responded to symptomatic treatment alone, but 1 child died