Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Symptom relief
RCT	31 Filipino children with secondary dengue infection receiving standard intravenous fluids according to WHO guidelines	Mean duration of severe thrombocytopenia 3.1 days with intravenous immunoglobulin (15 children) 2.5 days with no IVIG (16 children)	P = 0.11 The RCT is likely to have been underpowered to detect a clinically important difference.		Not significant
RCT	31 Filipino children with secondary dengue infection receiving standard intravenous fluids according to WHO guidelines	Mean increase in platelet counts (x103/microlitres) from day of initiation of IVIG treatment until day 7 of hospitalisation 54.9 with intravenous immunoglobulin (15 children) 48.0 with no IVIG (16 children)	P = 0.15 The RCT is likely to have been underpowered to detect a clinically important difference.		Not significant