TABLE 4.

Strategies in Myelodysplastic Syndrome

Lower Risk (Blasts<10%)	Higher Risk (Blasts ≥10%; cytogenetics with ≥ 3 abnormalities or with chromosome 7 abnormality)
Growth factors: Erythropoietin, G-CSF	Decitabine, 5-azacitidine
Immune therapy: Steroids, cyclosporin, antithymocyte globulin	Investigational
Lenalidomide: 5q31	Intensive chemotherapy (younger, karyotype diploid)
Decitabine, 5-azacitidine	Allogeneic stem cell transplantation
Investigational: clofarabine, homoharringtonine
Iron chelation	Iron chelation
Translocation (5; 12) or 5q33 variant (PDGFR-B): Imatinib	Translocation (5; 12) or 5q33 variant (PDGFR-B): Imatinib

G-CSF indicates granulocyte–colony-stimulating factor; PDGFR-B, platelet-derived growth factor receptor B.