Table 2.
Maternal weight gain and litter parameters of CD-1 mice exposed to [C4mim]Cl
| Treatment and dose (mg/kg/day) |
||||
|---|---|---|---|---|
| Vehicle Control |
[C4mim]Cl (113) |
[C4mim]Cl (169) |
[C4mim]Cl (225) |
|
| Maternal weight gain (g ± SEM) |
10.67 ± 0.39 | 10.29 ± 0.44 | 10.38 ± 0.42 | 9.28 ± 0.64 |
| Maternal | ||||
| Morbidity/Mortality (No./% affected dams) |
0 | 1/3.3 | 2/6.7 | 10/28.3a |
| Fetuses/litters examined | 489/36 | 288/23 | 319/26 | 314/23 |
| Implantations (mean ± SEM) |
13.97 ± 0.36 | 12.78 ± 0.55 | 13.40 ± 0.36 | 13.91 ± 0.44 |
| Resorbed or dead fetuses (No. ± SEM) |
2.77 ± 0.84 | 2.24 ± 0.88 | 6.20 ± 2.82 | 3.24 ± 0.98 |
| Litters with resorbed or dead fetuses (No./%) |
10/27.8 | 6/26.1 | 8/30.8 | 9/39.1 |
| Malformed fetuses (% ± SEM)b,c |
0.91 ± 0.44 | 1.09 ± 0.60 | 1.56 ± 0.76 | 2.47 ± 0.93 |
| Malformed fetuses (% affected litters)b |
11.1 | 13.0 | 15.4 | 26.1 |
| Supernumerary Ribs (% ± SEM) |
24.53 ± 4.16 | 16.49 ± 4.42 | 16.97 ± 4.17 | 18.10 ± 5.28 |
| Rudimentary Ribs (% ± SEM) |
18.85 ± 2.70 | 21.47 ± 4.50 | 12.72 ± 2.16a | 7.92 ± 2.35a |
a
Significantly different from all other mean values (P ≤ 0.01)
b
Fetuses displaying any gross malformation.
c
Grand mean of litter mean percentages.