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. Author manuscript; available in PMC: 2016 Feb 5.
Published in final edited form as: Mol Cell. 2015 Feb 5;57(3):537–551. doi: 10.1016/j.molcel.2015.01.002

Figure 5. Drp1 S616 is phosphorylated in human pancreatic ductal adenocarcinoma.

Figure 5

(A) Three serial sections were cut from formalin-fixed, paraffin-embedded sections from 12 pancreatic ductal adenocarcinomas and stained with Hematoxylin and Eosin (H&E) or antibodies against phospho-Drp1 (S616) and phospho-Erk1/2 (T202/Y204). Representative images of colocalization are shown from 6 tumors. Scale Bar = 100μm (IHC). (B) The levels of phospho-Drp1 (S616) and phospho-Erk1/2 (T202/Y204) staining, as well as the degree of co-localization, were determined for each of 12 pancreatic ductal adenocarcinomas examined. (C) Additional sections were cut from two of the tumors (7, 11) and stained with an anti-mitochondria antibody (MTC02) to detect mitochondria (red). Blue: DAPI. Scale Bar = 20μm.