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CMCase production at different levels of optimization.
| Process conditions | Level of scale | CMCase activity (U/mL) | Enhanced production (fold) |
|---|---|---|---|
| Without any optimization | Shake flask | 0.07 ± 0.02 | — |
| With only optimised medium | Shake flask | 0.43 ± 0.04 | 6 |
| With optimised medium + optimised physical parameters | Shake flask | 0.57 ± 0.01 | 8 |
| With optimised medium + optimised physical parameters | Bioreactor | 0.75 ± 0.03 | 11 |
Values are mean ± SE (n = 3).
