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. 2015 Apr 10;11(4):e1005160. doi: 10.1371/journal.pgen.1005160

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© 2015 Ng et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Schematic of generating Dmp1-Cre Recql4 ^+/+ and Recql4 ^fl/fl mice. (B) The assessment of Recql4 genomic excision in various tissues from Dmp1-Cre mice. (C) Gross body weights of male Dmp1-Cre Recql4 mice. n = 4 for Recql4 ^+/+, n = 6 for Recql4 ^fl/fl. (D) Measurement of tibiae from Dmp1-Cre Recql4 ^+/+ and Recql4 ^fl/fl mice. n = 4 for Recql4 ^+/+, n = 8 for Recql4 ^fl/fl. (E) Trabecular bone volume (BV/TV), trabecular separation (Tb.Sp), trabecular number (Tb.N), trabecular thickness (Tb.Th) of Dmp1-Cre Recql4 tibiae. (F) Cortical thickness (Ct.Th), cortical bone area (Ct. Ar), total cortical cross-sectional bone area (Tt.Ar) and cortical bone area fraction (Ct.Ar/Tt.Ar) of Dmp1-Cre Recql4 cortical tissue. Data from 9 week old male mice; n = 4 for Recql4 ^+/+, n = 8 for Recql4 ^fl/fl. Data presented as mean±SEM. *P<0.05 compared with Recql4 ^+/+, t-test.