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. 2015 Apr 10;10(4):e0123942. doi: 10.1371/journal.pone.0123942

Fig 1. A map of the target promoter region of candidate genes and the distribution of relevant transcription factor binding sites in the corresponding promoter regions of those genes.

Fig 1

Numbers refer to the transcriptional start position (TSP, +1), indicated by bold black arrows, and the 5’-position of exon 1 (black box). The gray boxes in the TLR4, Hp, and αS1-casein promoter regions indicate repeat elements. The position of the various transcription factors and restriction enzyme recognition sites are indicated by the respective symbols. The positions of primers used for CHART-PCR and the methylation assays are denoted by light black arrows. The promoter structure of αS1-casein has been described by Vanselow et al. The TSP of the SAA3 promoter was reported by Marilynn et al. The target promoter regions of candidate genes were identified by BLAST analyses as DNA-sequences that are 5’-upstream of the mRNA sequence deposited in the following NCBI files: NM_174198 (TLR4), NM_001038674 (LBP), NM_001040470 (Hp), and NW_003104637 (SAA3).