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. 2015 Apr 10;10(4):e0122953. doi: 10.1371/journal.pone.0122953

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Fig 1 — (A) Three siRNAs were designed to target the HIV-1 3′PPT region: siRNA-PPT1, siRNA-PPT2 and siRNA-PPT3 contain sequence matching nt9069-9089, nt9071-9091, and nt9076-9096 of HXB2, respectively. The sense, passenger strands of the respective siRNA duplexes are indicated and aligned with the corresponding 3’PPT and flanking sequences of NL4-3. Importantly, the targeted sequences within NL4-3, v120 and v126 virus strains are identical. (B) The efficiency of siRNA-PPT inhibition of HIV replication was monitored by RT activity assay.