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. 2015 Mar 5;3(3):e12303. doi: 10.14814/phy2.12303

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Verapamil significantly reduced the increase in unstimulated [Ca²⁺]i when KATP channels are blocked with 10 μmol/L glibenclamide. (A) Changes in unstimulated [Ca²⁺]i during fatigue for the three groups of control fibers as shown in Figure5A–C; (B) the same for glibenclamide-exposed fibers as shown in Figure6A–D, (C) for Kir6.2^-/- fibers in Figure7A–C and (D) for glibenclamide–verapamil-exposed fibers in Figure8A and B. Vertical bars represent the SE of the number of fibers as indicated in Figures8. Dashed horizontal line indicates the level at which unstimulated [Ca²⁺]i was significantly greater than the prefatigue level.