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. 2015 Mar 16;3(3):e12340. doi: 10.14814/phy2.12340

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Treatment with the antiangiogenesis drug NP-470 suppressed cardiac angiogenesis in β₂-TG hearts. WT and β₂-TG mice were treated with vehicle or TNP-470 for 2 weeks. (A) representative images showing dual-stained cardiomyocytes (WGA, green) and endothelial cells (IB4, red) of the LVs (n = 4–7/group). Bar = 50 μm. Capillary density was presented as the number of microvessels per cardiomyocyte. *P < 0.05 versus WT controls; ^#P < 0.05. (B) Representative ECG traces after 2 weeks administration of TNP-470. Arrows indicate the typical ischemia-like ST-depression and T-wave inversion in the β₂-TG mice treated with TNP-470. (C) Group analysis of ECG findings in WT and β₂-TG mice (n = 7–8/group). (D) survival curve of WT and β₂-TG mice during the 2 weeks period of TNP-470 treatment.