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. 2015 Mar 16;3(3):e12340. doi: 10.14814/phy2.12340

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Adverse functional consequence of TNP-470 treatment only in β₂-TG mice. Representative M-mode echocardiographic tracings from short-axis LV 2D images (A) and pressure–volume loops (B) from WT and β₂-TG mice after 2 weeks treatment with vehicle or TNP-470. (C) Echocardiographic analysis of mice before and after treatment with vehicle or TNP-470 (n = 8–9/group). FS, fractional shortening; LVDd and LVDs, LV dimensions at end-diastole and end-systole, respectively; WTh, ventricular wall thickness at end-diastole. *P < 0.05, **P < 0.01 respective TG versus WT group. P values indicate within-group comparison between WK0 and WK2 in TG-TNP group.