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. 2015 Mar 16;3(3):e12340. doi: 10.14814/phy2.12340

Table 3.

Hemodynamic parameters of WT and β2-TG mice at 2 weeks after treatment with vehicle or TNP-470

WT TG
Vehicle TNP470 Vehicle TNP470
Number 5 7 5 6
Heart rate, beats/min 487 ± 1 474 ± 14 565 ± 9* 532 ± 23*
LV systolic pressure, mmHg 98 ± 6 96 ± 2 92 ± 7 93 ± 2
End-diastolic pressure, mmHg 6 ± 1 5 ± 0 6 ± 2 11 ± 1*
End-diastolic volume, μL 38 ± 3 34 ± 3 33 ± 4 51 ± 2*#
End-systolic volume, μL 19 ± 3 13 ± 3 10 ± 3 21 ± 2*#
Ejection Fraction, % 54 ± 5 66 ± 5 72 ± 4* 58 ± 3#
Stroke Volume, μL 19 ± 1 21 ± 2 23 ± 2 30 ± 2*
dP/dtmax, mmHg/s 9645 ± 314 10526 ± 360 10866 ± 667 10057 ± 784
dP/dtmin, mmHg/s 7006 ± 415 7783 ± 291 8095 ± 673 7183 ± 662
τ, ms 6.7 ± 0.2 5.9 ± 0.3 5.2 ± 0.2* 6.9 ± 1.0
Ees, mmHg/μL 2.0 ± 0.2 2.0 ± 0.3 4.3 ± 0.5* 2.1 ± 0.5#
Preload adjusted maximal power, mW/mL2 80 ± 13 83 ± 12 148 ± 36 48 ± 5*#
dP/dt-EDV, mmHg/s/μL 152 ± 25 154 ± 16 397 ± 58* 95 ± 8*#
Mw, erg/cm3 per 103 47 ± 5 62 ± 6 85 ± 12* 53 ± 6#
EDPVR, mmHg/μL 0.28 ± 0.05 0.29 ± 0.06 0.37 ± 0.06 0.24 ± 0.08

*P < 0.05 versus WT mice; #P < 0.05 versus vehicle-treated β2-TG mice. LV, left ventricle; Ees, ventricular end-systolic elastance; EDV. end-diastolic volume; Mw, preload recruitable stroke work relationship; EDPVR, end-diastolic pressure–volume relationship.