Figure 2.

Treatment with CL 316,243 reduces epididymal adipose tissue weight independent of changes in body weight, food intake, and glucose tolerance. WT and whole-body IL-6^−/− mice were injected with CL (1.0 mg/kg bw) or an equivalent volume of sterile saline once per day for five consecutive days and (A) final body weight, (B) total food intake, (C) eWAT weight, (D) iWAT weight, (E) BAT weight and (F) the area under the curve (AUC) during a glucose tolerance test determined. Data are presented as mean + SEM for seven mice/group. *Significantly different than saline-treated group in the same genotype, P < 0.05.