Table 2. The distribution frequency of FGFR4 genotypes in 595 healthy controls and 289 patients with HCC.
| Variable | Controls (N = 595) n (%) | Patients (N = 289) n (%) | OR (95% CI) | AOR (95% CI) |
|---|---|---|---|---|
| rs1966265 | ||||
| GG | 151 (25.4%) | 65 (22.5%) | 1.00 | 1.00 |
| GA | 300 (50.4%) | 160 (55.4%) | 1.239 (0.875–1.755) | 1.167 (0.782–1.743) |
| AA | 144 (24.2%) | 64 (22.1%) | 1.032 (0.683–1.562) | 0.845 (0.521–1.371) |
| GA+AA | 444 (74.6%) | 224 (77.5%) | 1.172 (0.841–1.634) | 1.063 (0.724–1.560) |
| rs351855 | ||||
| CC (Gly/Gly) | 159 (26.7%) | 82 (28.4%) | 1.00 | 1.00 |
| CT (Gly/Arg) | 314 (52.8%) | 150 (51.9%) | 0.926 (0.666–1.288) | 0.994 (0.679–1.455) |
| TT (Arg/Arg) | 122 (20.5%) | 57 (19.7%) | 0.906 (0.600–1.368) | 1.039 (0.642–1.683) |
| CT+TT | 436 (73.3%) | 207 (71.6%) | 0.921 (0.673–1.260) | 1.005 (0.699–1.447) |
| rs2011077 | ||||
| GG | 147 (24.7%) | 66 (22.8%) | 1.00 | 1.00 |
| GA | 297 (49.9%) | 159 (55.0%) | 1.192 (0.842–1.689) | 1.079 (0.720–1.616) |
| AA | 151 (25.4%) | 64 (22.1%) | 0.944 (0.625–1.425) | 0.773 (0.478–1.252) |
| GA+AA | 448 (75.3%) | 223 (77.2%) | 1.109 (0.796–1.545) | 0.977 (0.664–1.438) |
| rs7708357 | ||||
| GG | 577 (97.0%) | 283 (97.9%) | 1.00 | 1.00 |
| GA | 18 (3.0%) | 5 (1.8%) | 0.566 (0.208–1.541) | 0.570 (0.190–1.707) |
| AA | 0 (0%) | 1 (0.3%) | ——- | —— |
| GA+AA | 18 (3.0%) | 6 (3.1%) | 0.680 (0.267–1.731) | 0.644 (0.225–1.840) |
The odds ratios (ORs) with their 95% confidence intervals (CIs) were estimated using logistic regression models. The adjusted odds ratios (AORs) with their 95% Cis were estimated using multiple logistic regression models after controlling for age and sex. * p < 0.05 was considered statistically significant.